It has been reported that those with weak hearts, e.g. the elderly, have arrested (heart stopped) while in the loo, doing the No.2.
This is the reason why.... when we're into No.2, our "rest-and-relax" aka parasympathetic system kicks is... this means blood is directed away from the muscles, and to the visceral organs (e.g. gut, kidneys)... and part of this effect is the slowing of heart rate (vagal activation).
Good to keep an eye out for friends/family that might be in this kind of situation.
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